In early 2005, The Game began a feud with G-Unit. Even before The Game's first album was released and their feud became public, there was tension between The Game and 50 Cent. Soon after The Documentary's release, 50 Cent felt that the rapper's actions in the strip club was wrong and then booted Game out of G-unit.
50 Cent also claimed that he was not getting his proper credit for the creation of the album and he claimed that he wrote six of the songs, but The Game denied that. During that dispute, a member of The Game's entourage was shot after a confrontation at the Hot 97 studio in New York City. After the situation between them escalated, 50 Cent and The Game held a press conference to announce their reconciliation. Fans had mixed feelings as to whether the rappers created a publicity stunt to boost the sales of the two albums the pair had just released. Nevertheless, even after the situation had apparently deflated, G-Unit continued to feud with The Game, denouncing his street credibility in the media and claimed that without their support, he will not score a hit from his second album. The Game responded during a performance at Summer Jam and launched a boycott of G-Unit called "G-Unot".
After the performance at Summer Jam, The Game responded with "300 Bars and Runnin'", an extended "diss" aimed at G-Unit as well as members of Roc-A-Fella Records on the mixtape You Know What It Is Vol. 3. 50 Cent responded through his "Piggy Bank" music video, which features The Game as a Mr. Potato Head doll and also parodies other rivals. Since then both groups continued to attack each other. The Game released two more mixtapes, Ghost Unit and a mixtape/DVD called Stop Snitchin, Stop Lyin.
50 Cent's rebuttal was "Not Rich, Still Lyin'" where he mocks The Game. In addition, G-Unit started to respond on numerous mixtapes and new G-Unit member Spider Loc began dissing The Game. The Game responded with "240 Bars (Spider Joke)", a song mainly aimed at Spider Loc, but also addressing Tony Yayo and rap group M.O.P., and on the song "The Funeral 100 Bars".
In October 2006, The Game extended a peace treaty to 50 Cent, which was not immediately replied to. However, a couple days later on Power 106, he stated that the treaty was only offered for one day. On The Game's album Doctor's Advocate, he says the beef is over on a few of the songs. The feud seemed to have gained steam after Tony Yayo allegedly slapped the fourteen year old son of Czar Entertainment CEO Jimmy Rosemond. The Game responded with "Body Bags" on You Know What It Is Vol. 4. Since Young Buck was dismissed from G-Unit by 50 Cent, there has been interviews from both The Game & Young Buck stating they never had a problem with each other. In an interview Young Buck says he is aware of The Game's support and says that is real love because Lloyd Banks & Tony Yayo haven't reached out to him.
